Department Introduction

Gastroenterology and Hepatology | Our Speciality

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Our Speciality

China Medical University Hospital | Digestive Medicine

Digestive Medicine

Precision Diagnosis and Integrated Minimally Invasive Pancreatobiliary Care | Precise Diagnosis, Management of Small Bowel Diseases | Precision Liver Tumor Ablation and Integrated Care

Pancreatobiliary Care | Small Bowel Diseases | Liver Tumor Ablation

Precision Diagnosis and Integrated Minimally Invasive Pancreatobiliary Care

01 Clinical Overview

We integrate pancreatobiliary endoscopy with interventional endoscopic ultrasound (EUS) to treat biliary and pancreatic diseases. Cholangioscopy- and pancreatoscopy-guided lithotripsy enable treatment of difficult stones. Our team provides specialist on-call support 24 hours a day for timely care.

02 Specialized Clinical Services

For stones in the bile duct, cystic duct or pancreatic duct, we combine endoscopic retrograde cholangiopancreatography (ERCP) with direct visualization using cholangioscopy or pancreatoscopy. Electrohydraulic lithotripsy (EHL) treats large, impacted stones or stones that are difficult to remove with conventional techniques. When ERCP fails or surgically altered anatomy limits access, interventional EUS can establish an access route for lithotripsy, reducing the need for surgery in selected patients. EUS enables tissue sampling of pancreatic tumors. EUS-guided interventions include drainage of pancreatic fluid collections, gallbladder drainage for acute cholecystitis, biliary and pancreatic duct drainage, and gastroenterostomy. Specialists provide on-call coverage throughout the year, working with emergency medicine, anesthesia, surgery and diagnostic imaging teams. Our 24-hour specialist service coordinates emergency treatment and follow-up. Assessment begins through the Emergency Department or an inpatient consultation.

Difficult Stones

Cholangioscopy- and Pancreatoscopy-Guided EHL

For stones in the bile duct, cystic duct or pancreatic duct, we combine endoscopic retrograde cholangiopancreatography (ERCP) with direct visualization using cholangioscopy or pancreatoscopy. Electrohydraulic lithotripsy (EHL) treats large, impacted stones or stones that are difficult to remove with conventional techniques. When ERCP fails or surgically altered anatomy limits access, interventional EUS can establish an access route for lithotripsy, reducing the need for surgery in selected patients.

Interventional Treatment

Endoscopic Ultrasound and EUS-Guided Interventions

EUS enables tissue sampling of pancreatic tumors. EUS-guided interventions include drainage of pancreatic fluid collections, gallbladder drainage for acute cholecystitis, biliary and pancreatic duct drainage, and gastroenterostomy.

Emergency Care

24-Hour On-Call Specialist Support

Specialists provide on-call coverage throughout the year, working with emergency medicine, anesthesia, surgery and diagnostic imaging teams. Our 24-hour specialist service coordinates emergency treatment and follow-up. Assessment begins through the Emergency Department or an inpatient consultation.

Electrohydraulic lithotripsy was performed via cholangioscopy to fragment and extract the impacted bile duct stone.
Electrohydraulic lithotripsy was performed via cholangioscopy to fragment and extract the impacted bile duct stone.
In symptomatic pancreatic duct stone patients with surgically altered anatomy, endoscopic ultrasound-guided pancreaticogastrostomy (EUS-PGS) was utilized to allow a pancreatoscope to access the pancreatic duct through the created route for lithotripsy.
In symptomatic pancreatic duct stone patients with surgically altered anatomy, endoscopic ultrasound-guided pancreaticogastrostomy (EUS-PGS) was utilized to allow a pancreatoscope to access the pancreatic duct through the created route for lithotripsy.
Endoscopic ultrasound-guided gallbladder drainage; Pancreatic cancer with gastric outlet obstruction Endoscopic ultrasound-guided gastroenterostomy
Endoscopic ultrasound-guided gallbladder drainage; Pancreatic cancer with gastric outlet obstruction Endoscopic ultrasound-guided gastroenterostomy

03 Representative Research Publications

Endoscopic ultrasound-guided gastroenterostomy, with focus on technique and practical tips.

Clinical Endoscopy. 2025;58:201–217. DOI: 10.5946/ce.2024.206 A review from our department on interventional EUS: techniques and experience in managing complications.

Risk factors related to age at diagnosis of pancreatic cancer: a retrospective cohort pilot study.

BMC Gastroenterology. 2022;22:243. DOI: 10.1186/s12876-022-02325-7 Our institution’s capabilities in pancreatic cancer research, risk assessment, and clinical studies.

Endoscopic ultrasound-guided fine-needle biopsy as a tool for studying the intra-tumoral microbiome in pancreatic ductal adenocarcinoma: a pilot study.

Scientific Reports. 2022;12:107. DOI: 10.1038/s41598-021-04095-w Research on pancreatic cancer and probiotics.

04 Quality Recognition and Specialized Training

2023

Symbol of National Quality (SNQ)

2023 Symbol of national Quality (S010297). Pancreaticobiliary Endoscopy Team: Unique Interventional ERCP Training Center in Taiwan.

05 Medical Teams and Access to Care

Pancreatobiliary Endoscopy Team: Wen-Hsin Huang, Chi-Ying Yang, Shih-Chieh Chuang, Cheng-Hsing Hung, Tsung-Lin Hsieh, Yu-Chen Chang, Chin-Wei Chang

Outpatient Appointments: Visit the hospital website, select “Online Appointment Booking,” and choose Digestive Medicine and an appropriate physician. Referrals: Please use the hospital’s referral service. Patients with fever accompanied by jaundice or significant gastrointestinal bleeding should seek care at the Emergency Department. The team will arrange treatment according to the patient’s clinical condition.

Digestive Medicine and AppointmentsDigestive Medicine Team

Synergizing Ultrasound and Dual Endoscopy: Precision Theranostics for Gut Health

01 Clinical Overview

Capsule endoscopy and double-balloon enteroscopy are used for disease localization and diagnosis—enabling precise small bowel lesion localization, histological diagnosis, and minimally invasive therapy—combined with intestinal ultrasound to evaluate early treatment response in small bowel lesions and inflammatory bowel disease (IBD).

02 Specialized Clinical Services

For obscure gastrointestinal bleeding, small bowel tumors, and Crohn's disease, capsule endoscopy is utilized to localize lesions, followed by deep enteroscopy for biopsy, hemostasis, and lesion-specific interventions. Intestinal ultrasound provides radiation-free, repeatable evaluations of the bowel wall and surrounding tissues, facilitating the assessment of inflammation severity and early treatment response. By integrating endoscopy, imaging, pathology, surgery, and nutritional care, follow-up plans are tailored to specific disease characteristics, establishing a continuum of care that encompasses diagnosis, treatment, and long-term disease monitoring.

Lesion Localization

Capsule Endoscopy

Capsule endoscopy is utilized to localize lesions.

Targeted Intervention

Double-Balloon Enteroscopy

Deep enteroscopy for biopsy, hemostasis, and lesion-specific interventions.

Ongoing Monitoring

Intestinal Ultrasound

Radiation-Free, Repeatable, Real-Time Assessment

Intestinal ultrasound: Using intestinal ultrasound to detect blood flow intensity helps determine the severity of bowel wall inflammation
Intestinal ultrasound: Using intestinal ultrasound to detect blood flow intensity helps determine the severity of bowel wall inflammation
Inter-Hospital Intestinal Ultrasound Workshop
Inter-Hospital Intestinal Ultrasound Workshop
Capsule endoscopy: Blue rubber bleb nevus syndrome

03 Representative Research Publications

Plasma Immunoglobulin A and intestinal ultrasound: Novel indicators for disease activity monitoring in inflammatory bowel disease—Insights from a Taiwan cohort.

Advances in Digestive Medicine. 2026;13:e70016. DOI: 10.1002/aid2.70016 A study conducted at our hospital integrating biomarkers and intestinal ultrasound for the assessment of disease activity.

Meckel’s diverticulum diagnosed by double-balloon enteroscopy: A single-center retrospective study in Taiwan.

JGH Open. 2022;6:63–68. DOI: 10.1002/jgh3.12697 Single-Center Study: Clinical Experience in Diagnosing Etiologies of Small Bowel Bleeding via Deep Enteroscopy.

04 Quality Recognition and International Training

2025

Symbol of National Quality (SNQ)

2025 Symbol of national Quality (S010980). Comprehensive Medical Care for Patients with Inflammatory Bowel Disease.

2026

IBUS Module 2 International Training Center

2026 IBUS Module 2 International Training Center. Qualification: Intestinal Ultrasound Education and Training.

05 Medical Teams and Access to Care

Small Bowel Team: Jen-Wei Chou, Yi-Hua Wu, Po-Ju Huang

Intestinal Ultrasound: Tsung-Yu Tsai

Outpatient Appointments: Visit the hospital website, select “Online Appointment Booking,” and choose Digestive Medicine and an appropriate physician. Referrals: Please use the hospital’s referral service. Patients with fever accompanied by jaundice or significant gastrointestinal bleeding should seek care at the Emergency Department. The team will arrange treatment according to the patient’s clinical condition.

Digestive Medicine and AppointmentsDigestive Medicine Team

Precision Image-Guided Liver Tumor Ablation and Integrated Care

01 Clinical Overview

By integrating Sonazoid contrast-enhanced ultrasonography, CT/MRI–ultrasound fusion imaging, and radiofrequency and microwave ablation, we provide precision, minimally invasive treatment for liver tumors. Anesthesiologist-managed sedation and intraoperative monitoring enhance patient comfort, while emphasizing preservation of liver function and comprehensive follow-up care.

02 Specialized Clinical Services

China Medical University Hospital integrates Sonazoid contrast-enhanced ultrasonography (CEUS), CT/MRI–ultrasound fusion imaging guidance, and radiofrequency ablation (RFA) and microwave ablation (MWA) to facilitate precise identification, localization, and individualized treatment planning for liver tumors. Treatment strategies are tailored by a multidisciplinary hepatology team according to liver cancer stage, tumor size and location, and underlying liver function. Anesthesiologists provide sedation and continuous intraoperative monitoring to enhance patient comfort and minimize procedural discomfort. Following treatment, patients receive comprehensive care incorporating imaging surveillance, monitoring for tumor recurrence, liver function management, and coordinated multidisciplinary treatment when indicated. This integrated approach supports continuity of care and long-term liver health.

Enhanced Visualization

Sonazoid Contrast-Enhanced Ultrasonography (CEUS)

Provides additional imaging information during the vascular and Kupffer phases, facilitating accurate detection and localization of liver lesions.

Image-Guided Localization

CT/MRI–Ultrasound Fusion Imaging Guidance

Integrates preprocedural CT/MRI images with real-time ultrasonography to improve localization of liver lesions that are difficult to visualize using conventional ultrasound alone.

Minimally Invasive Treatment

Minimally Invasive RFA / MWA

Individualized local ablation strategies based on tumor size, location, number of lesions, and underlying liver function.

Anesthesia Care

Anesthesiologist-Managed Sedation and Monitoring

Sedation and continuous intraoperative monitoring provided by anesthesiologists to enhance patient comfort and minimize procedural pain and discomfort.

Figure 1: Contrast-enhanced ultrasound during the arterial phase. Figure 2: Contrast-enhanced ultrasound during the Kupffer phase.
Figure 1: Contrast-enhanced ultrasound during the arterial phase. Figure 2: Contrast-enhanced ultrasound during the Kupffer phase.
CT–ultrasound fusion imaging demonstrating the localization of a hepatic lesion by combining real-time ultrasound with preprocedural CT images. Ultrasound-guided liver tumor localization using CT/MRI–ultrasound fusion imaging at China Medical University Hospital.
CT–ultrasound fusion imaging demonstrating the localization of a hepatic lesion by combining real-time ultrasound with preprocedural CT images. Ultrasound-guided liver tumor localization using CT/MRI–ultrasound fusion imaging at China Medical University Hospital.
Comparison of radiofrequency ablation (RFA) and microwave ablation (MWA), illustrating their mechanisms of thermal energy delivery and tissue destruction. Ultrasound-guided percutaneous liver tumor ablation performed by the hepatology team at China Medical University Hospital.
Comparison of radiofrequency ablation (RFA) and microwave ablation (MWA), illustrating their mechanisms of thermal energy delivery and tissue destruction. Ultrasound-guided percutaneous liver tumor ablation performed by the hepatology team at China Medical University Hospital.

Integrated Care Pathway for Local Tumor Ablation

01Pre-Treatment AssessmentBCLC staging, tumor number and location, Child–Pugh class and ALBI grade, diagnostic imaging, and anesthesia risk assessment.
02Precision Ablation and Intraoperative CareSonazoid-enhanced ultrasound and CT/MRI–ultrasound fusion imaging for tumor localization; RFA or MWA with anesthesiologist-managed sedation and continuous vital sign monitoring.
03Post-Treatment Follow-Up and CarePost-ablation imaging assessment, complication monitoring, liver function management, recurrence surveillance, and multidisciplinary retreatment when indicated.

Important Safety Information: The term “painless sedation anesthesia” is used by our hospital to describe its anesthesia services. The actual anesthesia technique is individualized according to each patient's clinical condition and risk assessment. Complete freedom from pain or complications cannot be guaranteed.

03 Representative Research Publications

Predictors of response and survival in patients with unresectable hepatocellular carcinoma treated with nivolumab: real-world experience.

American Journal of Cancer Research. 2020;10(12):4547–4560. PMID: 33415018 Identification of predictors associated with immunotherapy response and survival in patients with unresectable hepatocellular carcinoma (HCC).

On-Treatment Albumin-Bilirubin Grade: Predictor of Response and Outcome of Sorafenib-Regorafenib Sequential Therapy in Patients with Unresectable Hepatocellular Carcinoma.

Cancers. 2021;13(15):3758. DOI: 10.3390/cancers13153758 Demonstration of the prognostic value of on-treatment albumin-bilirubin (ALBI) grade for predicting treatment response and clinical outcomes during sequential targeted therapy.

Alpha-fetoprotein response predicts treatment outcomes in patients with unresectable hepatocellular carcinoma receiving immune checkpoint inhibitors with or without tyrosine kinase inhibitors or locoregional therapies.

American Journal of Cancer Research. 2021;11(12):6173–6187. PMID: 35018250 Evaluation of dynamic alpha-fetoprotein (AFP) response as a biomarker for predicting treatment outcomes in patients receiving immune checkpoint inhibitor–based therapy.

Real-world experience of lenvatinib-based therapy in patients with advanced hepatocellular carcinoma.

Journal of Gastrointestinal Oncology. 2024;15(5):2216–2229. DOI: 10.21037/jgo-24-351 Assessment of real-world clinical outcomes associated with lenvatinib-based targeted therapy and combination treatment strategies in patients with advanced HCC.

These publications reflect the liver cancer team’s research in treatment strategies, risk stratification, and real-world outcomes. They do not constitute a direct institutional comparison of RFA and MWA outcomes.

04 Medical Teams and Access to Care

Local Ablation: Hung-Wei Wang, Wei-Fan Hsu

Digestive Medicine and Multidisciplinary Liver Cancer Team: Hung-Wei Wang, Wei-Fan Hsu, Tzu-Hao Yen

Outpatient Appointments: Visit the hospital website, select “Online Appointment Booking,” and choose Digestive Medicine and an appropriate physician. Referrals: Please use the hospital’s referral service. Patients with fever accompanied by jaundice or significant gastrointestinal bleeding should seek care at the Emergency Department. The team will arrange treatment according to the patient’s clinical condition.

Digestive Medicine and AppointmentsDigestive Medicine Team
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